healthcare · governed processFDA/EMA

Pharmacovigilance automation software

Build the Pharmacovigilance flow once, AI agents run it end to end, and governance keeps a human on the risky, irreversible steps. That's pharmacovigilance automation with human sign-off FDA/EMA-aligned automation you can defend to an auditor.

Build this flow →How AI-native BPM works
13
Workflow steps
1
Human sign-off gates
FDA/EMA
Regulator
Always
Human on risky steps
What the Pharmacovigilance flow does

A 13-step governed process, not a black box.

The Pharmacovigilance workflow breaks pharmacovigilance into 13 discrete, ordered steps. Specialist AI agents execute each one; a gate resolver scores every step by blast radius and reversibility, parking the 1 riskiest, irreversible step for a human to sign off. Because pharmacovigilance is governed by FDA/EMA, the flow emits FDA/EMA evidence as it runs and records every decision with a tamper-evident audit hash.

01

Agents run the volume

Specialist agents work the 13 steps of pharmacovigilance end to end — the reversible, low-risk work clears automatically.

02

1 human gate

The gate resolver parks the 1 irreversible, high-blast-radius step for a person. Nothing high-stakes auto-clears until a tier has earned it.

03

FDA/EMA evidence

FDA/EMA-aligned evidence is emitted as the process runs — logged with tier, resolver, confidence and an audit hash.

The built process

Pharmacovigilance autopilot

Pharmacovigilance is high-volume ICSR processing under a 15-day expedited clock, where a named QPPV is legally accountable for every causality and seriousness call. Cases coded, de-duplicated and causality-assessed straight-through; the QPPV signs before any safety report is submitted.

8 agent steps1 human gatesigns: QPPV / drug-safety physicianquality 87/100
The governed flow · branches, parallel work & a human on the irreversible step
invalid / incompletevalid casenon-seriousserious / expeditedrejected — re-assesssigned
Start
agent · low risk
Intake the adverse-event case (ICSR) from the source and capture reporter, product and event fields
decision
Case valid & complete (identifiable patient, reporter, product, event)?
agent · low risk
Request follow-up from the source to obtain the missing minimum criteria, then re-intake
parallel · fan-out / join
Run coding, causality and seriousness assessment concurrently on the valid case
agent · low risk
MedDRA-code the terms and de-duplicate against the safety database
agent · low risk
Assess drug-event causality
agent · medium risk
Triage seriousness / expectedness and start the 15-day expedited-reporting clock
parallel · fan-out / join
Join the parallel assessment branches into a single case assessment
decision
Serious / expedited-reportable case?
agent · low risk
Auto-log the non-serious case to the safety database for periodic (PSUR) aggregation; no expedited report
gate · human sign-off
Review the causality, seriousness and E2B report; sign or reject the case assessmentsigns: QPPV / drug-safety physician
agent · high riskirreversible
Submit the safety report (E2B) to FAERS / EudraVigilance
agent · low risk
Run signal detection and maintain the safety database
Done
low riskmedium / branchhigh riskgate · human sign-offstart / done
Governed pharmacovigilance automation

Why teams choose Minctrl to automate pharmacovigilance.

Most tools that promise pharmacovigilance automation software either fully automate and lose the audit trail, or bolt AI onto a form and still route every case to a human. Minctrl is different: it's an AI-native workflow builder for regulated operations. You design pharmacovigilance once as the Pharmacovigilance flow, AI agents run it, and a governance layer keeps a human on the steps where a mistake is irreversible.

The Pharmacovigilance agent handles pharmacovigilance the way an experienced operator would — gathering inputs, applying policy, and drafting the decision — while the governance layer decides, step by step, whether it can clear automatically or needs a human. This is what makes pharmacovigilance automation with human sign-off practical rather than a slogan: the AI does the 13-step work; the person owns the1 decision that actually carry risk.

Whether you want to automate pharmacovigilance, deploy an AI pharmacovigilance agent, or roll out full pharmacovigilance workflow automation under FDA/EMA compliance, the flow ships with the governance, the human gates and the tamper-evident audit trail already wired in. Advisory first — a tier only earns autonomy after it's calibrated — so you can adopt pharmacovigilance automation software without changing the human sign-off until you're ready.

pharmacovigilance automation with human sign-offautomate pharmacovigilancepharmacovigilance workflow automationAI pharmacovigilance agentpharmacovigilance FDA/EMA compliancehow to automate pharmacovigilance
FAQ

Questions about pharmacovigilance automation.

How do you automate pharmacovigilance?

Minctrl models pharmacovigilance as a governed workflow of 13 steps. Specialist AI agents run each step; a governance layer scores every step by blast radius and reversibility and parks the risky, irreversible ones for a human at 1 sign-off gate. Build the Pharmacovigilance flow once, agents run it, and governance keeps a human on the steps that count.

Is Pharmacovigilance automation FDA/EMA-compliant?

Every gate decision in the Pharmacovigilance flow is recorded with its tier, resolver, confidence and an audit hash, and runs are deterministic — an auditor re-running the flow gets the same result. FDA/EMA evidence is emitted as the process runs, not reconstructed afterward.

Does the AI decide everything, or is there human sign-off?

There is always human sign-off on the risky steps. The default is SAFE: any irreversible or high-blast-radius step in pharmacovigilance parks for a human. The AI clears the reversible, low-risk volume; a person signs off exactly where it matters — that's pharmacovigilance automation with human sign-off.

Keep exploring
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AI-native BPM

The engine underneath: AI runs the process, governance decides the gates.

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Build your Pharmacovigilance flow.

Governed automation with human sign-off on the risky steps and a tamper-evident audit trail. Free tier — bring your own LLM key.

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